World Trade Center (WTC) respondents with prostate cancer showed signs that dust exposure from the World Trade Center site had triggered chronic inflammation in their prostates, which may have contributed to the cancer, according to a study by researchers of Mount Sinai. Molecular Cancer Research in June.
Inflammation has been considered an important factor in the progression of prostate cancer. The researchers looked at the inflammatory and immune systems of the World Trade Center's response professionals to help prevent new cases of prostate cancer in this group and understand how other large-scale environmental exposures to various carcinogens can turn cancer.
This is the first study of people who were exposed to WTC powder and who subsequently developed prostate cancer. This research and further study of gene expression and pathways in other patients whose environmental exposures have caused inflammation may lead to clinical trials that offer anti-inflammatory or immuno-targeting therapies in similar cases.
"World Trade Center attendants show an overall increase in cancer incidence and specifically certain cancers, such as prostate cancer," said Emanuela Taioli, MD, PhD, director of the Institute of Translational Epidemiology at the Icahn School of Medicine, Mount Sinai and Associate Director of Population Science at The Tisch Cancer Institute. "It's important to address the reasons why this is happening to avoid new cases in this aging cohort." Our findings represent the first link between World Trade Center dust exposure and prostate cancer. "
This work combines data from first responders and a study of rats exposed to the actual dust of Ground Zero. Dust samples containing metals and organic compounds such as polycyclic aromatic hydrocarbons and polychlorinated biphenyl are unique because they are the only existing samples collected on September 11, 2001. All other dust samples were collected after a significant storm in 14 of September 2001..
Both rat and human prostate cancer tissues show an increase in cells that indicate inflammation, specifically immune cells called helper T cells. Studies of tissue samples from rats and prostate cancer taken from responders indicated to Mount Sinai researchers that chronic inflammation began to occur in the prostate after exposure to dust from the World Trade Center, and that inflammation may have contributed to prostate cancer .
Several years ago, I saw a first responder in his 40s who started having symptoms of prostatitis, a painful condition that involves inflammation of the prostate, right after exposure to dust from the World Trade Center. He finally developed a high-grade prostate cancer several years later. He suggested that there might be a link between his exposure and cancer, but I knew I would need to systematically examine it. "
William Oh, MD, Chief of the Division of Hematology and Medical Oncology at Icahn School of Medicine at Mount Sinai and Deputy Director of The Tisch Cancer Institute
The Mount Sinai Hospital / Mount Sinai School of Medicine
Oh, W.K. et al. (2019) Prostate Cancer in World Trade Center Respondents Demonstrates Evidence of an Inflammatory Cascade. Molecular Cancer Research. doi.org 10.1158 / 1541-7786.MCR-19-0115.