Researchers Create Proteins That Can Help Create Antibodies To Fight HIV



Researchers at the Penn State School of Medicine have created proteins that mimic different surface characteristics of HIV that could help create antibodies to fight the virus.

"We have shown that using our modified proteins, blood can spontaneously generate antibodies that can inhibit HIV infection in cellular models," said the scientists, whose work was published in the journal Nature Communications.

The researchers used computer models to design proteins that mimic the preserved protein surface of different strains of HIV for use in the vaccine. While proteins are usually designed by changing one amino acid at a time, the experts wanted to try a different approach.

After creating immunogens that used the new proteins that mimic HIV, they immunized the rabbits and extracted blood samples once a month. Thus, after analyzing the samples, the researchers found that the blood contained antibodies that could bind to HIV.

"While the findings are promising, there is still more work to be done, it is important that we can generate an immune response to HIV and show that this is possible as proof of concept, but we still need to improve antibody neutralization capabilities and other aspects. before it became a viable vaccine, "experts said.


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