"Neuron form" determines the effect of antidepressants



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London Katia Smith

Scientists believe that antidepressants do not work with more than 30% of people who suffer from them because of the different form of their neurons, being the most common inhibitor of serotonin reuptake the most common treatment for the disease.

The major depressive disorder is the most common cause of depression in the United States, for people between 15 and 44 years old, symptoms of the disease, feeling very sad or losing interest in most activities, affecting 16.1 million adults, E American depression.

But we still do not know what causes depression, although a well-known theory claims that low levels of serotonin neurotransmitters may play a role in this, impeding the absorption of the neurotransmitter in the neuron.

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The researchers said that investigating the reasons why some people did not improve after taking these drugs can be difficult. There are about 300,000 serotonin neurons that are difficult to reach from the 100 billion nerve cells in the brain. It is difficult to know if the differences in brain scan or postmortem images of brain tissue were caused by depression, prolonged use of drugs or biological causes.

Of the 803 patients with major depressive disorders, the researchers chose 3 that improved their condition after taking the drug, and 3 others did not respond to the treatment, did skin biopsies and the scientists turned the skin cells into multiple-capacity stem cells, He studied in vitro, and found that those who did not respond to antidepressants had higher neuronal projections than those who had symptoms after taking drugs, and had lower levels of two genes in the brain.

"With each new study, we approach a more comprehensive understanding of complex neurological circuits that cause neurological and psychiatric disorders, including severe depression."

"This is the first study to present a new model for the study of serotonin neurons, removing them from the skin cells of patients who do not respond to antidepressant therapy," said Dr. Valentina Mosenko, neuroscientist at the Faculty of Medicine and Health of the University of Exeter.

"This study allowed us to take a rare look at the fundamental characteristics of neurons that produce serotonin neurotransmitters in the brain," said Ulrich Burch, a researcher at the University of Bristol in the UK. "This study is interesting because it compares neurons from patients who have responded to cell therapy. There are not enough studies to solve this problem."

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