Mushroom drug improves renal water balance



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Fluconazole, an approved anti-fungal medicine, has discovered surprising new properties. The substance helps extract water from the urine, as rodent experiments have suggested. The path to a therapeutic therapeutic application z. However, in rare genetic kidney disease is still not so easy.

More water back to the body

Fluconazole, an approved anti-fungal medicine, has discovered surprising new properties. The substance helps extract water from the urine, as rodent experiments have suggested. The path to a therapeutic therapeutic application z. However, in rare genetic kidney disease is still not so easy.

Up until 20 liters of urine run into the bathroom every dayand they also have to drink both, This limits the life of patients with water hammers (Diabetes insipidustightly. The kidneys do not drain enough of the urine water. it is may have genetic causes, but also be triggered by drugs, for example, These people could in the future be a true antifungal drug called fluconazole help.

Fluconazole brings more water back into the body.

The drug is activated. aquaporins in the kidney cells, which are stored in small supply vesicles. Once activated, they form Poros on the surface of the cell through which water molecules flow can. O Kidneys carry water from the urine back to the body.,

Usually this goes Precisely controlled process by the hormone vasopressinIf the hormone is missing or can not function in the cell, it can lead to massive loss of free water through the urine. fluconazole Interestingly, even without hormone, at least to some extent Water resources for regular, About 30% of normal water recovery can restore fluconazole even without vasopressin in mice.

No therapy for all patients

Fluconazole is only useful something if in the renal cell the machinery for the aquaporins is still intact, Patients whose Mutated Aquaporin gene and it could be a future therapy with fluconazole for example Does'nt help,

There is hope, however, for those affected whose body produces too little vasopressin for hereditary reasons, or whose renal cells are insensitive to the hormone due to a mutation. In addition, about half of people who need to take lithium as a drug, plenty of water. In addition, your kidneys are no longer responsive enough for the hormone and could in principle benefit from fluconazole,

Effect on the cells of the kidney channels

Each person produces in their kidneys a total of 180 liters of primary urine. In the end, however, only a few liters per day can emerge as urine. For this purpose, the tiny tubes that guide the urine to the renal pelvis extract more or less water from the fluid as needed. Decisive to the hormonally controlled fine tuning of this process are the multiples.

At this point, the "rediscovered" fungal medication intervenes. Under the influence of the drug The aquaporins migrated to the surface the cell. also improved Fluconazole Transport of water in collecting pipes of rat animals,

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