Coffee protects against fatty liver caused by a high fat diet



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Coffee consumption is inversely associated with the risk of non-alcoholic fatty liver disease (NAFLD). There is also a gap in the literature on the gastrointestinal mechanisms involved in the effect of coffee consumption on the prevention of non-alcoholic fatty liver disease. In a study published by the University of Cambridge in the Journal of Natural Science, 24 rats were divided into 3 groups, each subject to a specific diet for 12 weeks: the first standard diet and the second high fat diet and the third diet rich in fat with coffee. Decaffeinated. The study concluded that coffee consumption reduced liver lipid degeneration caused by the high fat diet and also reduced cholesterol and glucose levels.

Compared to mice that were only submitted to high fat diets, mice with the same regimen but with coffee presented higher amounts of undigested fat in the colon and more free fatty acids in the 12 and in the colon. Rats who drank coffee had a similar amount of energy compared to those who had a high-fat diet without coffee, but from the eighth week of intervention, the coffee group gained significantly less weight over time. The data completely showed that coffee prevented the incidence of non-alcoholic fatty liver disease caused by the hyperlipidic diet in mice, reducing liver fat deposition and metabolic abnormalities, modifying the pathways that support lipid oxidation in the liver, the flow of cholesterol in the intestine , energy metabolism and intestinal permeability. . The hepatocellular benefits and the coffee-induced metabolism were also accompanied by changes in the small intestine.

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