Named the cause of increased sensitivity of women to systemic lupus erythematosus



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Among the wide variety of various types of diseases, so-called autoimmune diseases hold a special place. As the name implies, in this case there is a pathological production of autoimmune antibodies – or the reproduction of autoaggressive clones of killer cells directed against the healthy tissues of the body. In other words, the cells of the immune system begin to attack healthy tissues, which can have sadder consequences. Autoimmune diseases include multiple sclerosis, systemic lupus erythematosus, type 1 diabetes, and arthritis.

In systemic lupus erythematosus, patients often experience sudden increases in temperature, weakness, headaches, muscle aches and increased fatigue.

When combined with several other specific symptoms, doctors can diagnose the disease and prescribe treatment. Unfortunately, there are no effective remedies for the disease today. The doctor may prescribe glucocorticosteroids or, for example, stem cell therapy as a possible countermeasure.

The estimated survival for systemic lupus erythematosus 10 years after diagnosis is 80% and 20% after 60%.

Scientists have now made another major breakthrough in the fight against serious diseases. They found the possible reason why the disease affects women 12 times more often. According to experts, the reasons for this may be considered an additional X chromosome and an incomplete blocking of their work in the cells of the immune system. "I think this is a very important discovery. If we can get RNAs blocking the "off" X-chromosome reading to work normally, then we can suppress those breaks in the work of genes that are presumably related to the development of lupus, "said the University of Pennsylvania representative in Philadelphia Montserrat Anguera . (Montserrat Anguera).

The X chromosome is the sex chromosome. Mammalian females have two X chromosomes, and males have one X chromosome and one Y chromosome.

The scientists made their findings by analyzing the functioning of the Xist gene in lymphocytes from laboratory mice. This segment of DNA is responsible for assembling RNA molecules that prevent enzymes from reading the X chromosome. Researchers associate an "incompletely enclosed" X chromosome with a low concentration of the Xist gene, which increases the risk of a self- immune.

Earlier, we recall, scientists have suggested that electronic cigarettes can cause a pathological immune response in the lungs.

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