They create CRISPR device to detect genetic changes in minutes ~ Future EFE



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Several petri dishes in a laboratory. .EFE / JORGE DIRKX.

This new portable digital instrument, developed by the University of California at Berkeley, can also be used to assess the accuracy of genetic editing techniques, experts say.

To test their effectiveness, they used this device, nicknamed CRISPR-Chip, with which they can identify genetic mutations in DNA samples from patients with Duchenne muscular dystrophy (DMD), the most common during childhood.

"We developed the first transistor that uses CRISPR-Cas9 to look for possible mutations in the genome. You just need to put a purified DNA sample on the chip, let the CRISPR search and the graphene transistor return the results in minutes," said Kiana Aran, lead author of the study, said in a statement.

Work "on site"

In this way, doctors and geneticists can now sequence DNA to identify underlying genetic mutations in a wide variety of conditions and characteristics, while commercial companies dedicated to producing genealogical reports can also offer this new service to clients, the note adds.

The main advantage of CRISPR-Chip is that, unlike other genetic tests that also use this "cut and paste" technique, the use of highly sensitive graphene-based nanoelectronic components eliminates the need to send samples. to a laboratory.

"CRISPR-Chip really works on the floor. It can be done at the bedside (of a patient) if you have a good DNA sample," said co-author Niren Murthy, a professor of bioengineering in Berkeley. EFE

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