Discover the relationship between inhibition of the nervous system and surviving heart disease


Chilean researchers have found that inhibiting the nervous system during heart disease improves patient survival by up to 25%, according to EFE.

The discovery corresponds to a work by Drs. Rodrigo del Río and Nibaldo Inestrosa, belonging to the Centers of Excellence in Biomedicine of Magalhães (Cebima), and Aging and Regeneration (CARE Chile UC), held in Santiago and Punta Arenas.

According to Inestrosa, winner of the National Prize for Natural Sciences, in 2008, when manipulating the nervous system, survival in cases that presented heart failure increases by 25%, and there is also an improvement in the sequelae of the disease, which in many cases can be irreversible.

This is due to the fact that researchers have been able to identify and manipulate areas of the brain that contribute to the progression of the disease and the general deterioration of heart failure.

"We discovered that there is a very close relationship between the cerebral nuclei that control ventilation or breathing and the cardiovascular part," explained Dr. Rodrigo del Río.

The researchers also believe that this brain-heart relationship would also contribute to the progression of several cardiovascular pathologies, such as stroke, since data obtained in post-stroke patients show a change in the neural control of cardiovascular function .

In this context, the team led by Del Rio is focused on developing a clinical guide to establish effective therapies for the treatment of stroke and cardiovascular system recovery by stimulating certain areas of the brain.

"Currently, existing therapies are aimed at recovering mobility, talking, etc., but forget that the cause of this accident is usually heart disease that came from before: an untreated hypertension, an increase in sympathetic activity. in account, "he warned.

For Nibaldo Inestrosa, it is imperative that after a cerebrovascular accident there is a recovery at the heart level "in parallel with motor and speech therapies", because in this way "we can avoid that patients who previously had a stroke return to manifest the disease."

The collaborative work that fits this research, according to the Inestrosa, allowed to establish that, in both study models and patients, there would be a certain cognitive impairment that would be related to the phenomenon of cardiorespiratory dysfunction.

"We believe that both in people and in preclinical models of heart failure, there is memory damage, which would probably be associated with erratic convergence between the respiratory and cardiovascular nuclei," Del Rio said.

The team is now applying techniques based on optogenetic and chemogenetic controls at the neuronal level. This, he emphasized, "means that we have the possibility to stimulate a neuron from a breathing zone with light and then see how the cardiovascular cell behaves."

"We can also see the impact on the hippocampus and how they globally affect that heart now, which in the past could not be done because it was very difficult to select specific populations, but we now have that capability," he said.

The results of this study were published in the past in the journal Nature's Pediatric Reaserch.

In Chile, cardiovascular diseases caused by disorders of the heart and blood vessels, such as heart attacks and strokes, are the leading cause of death, with 27.2% of all deaths, according to data from the National Institute of Statistics (INE) .

They are accompanied by cancer in its various manifestations, such as 25% and respiratory diseases, as a cause of 9.5% of deaths.


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