MIS-C is a new syndrome that can occur in children and adolescents after infection with the SARS-CoV-2 coronavirus.
The abbreviation MIS-C is derived from the name of the disease in English – “Multisystem Inflammatory Syndrome in children”.
In Norwegian, the full name is “multiorgan inflammatory syndrome in children”.
The disease is associated with an inflammatory condition in several organs, such as skin, mucous membranes, heart, lungs, gastrointestinal tract, liver and kidneys, after suffering from covid-19 disease.
Recent US figures
Since mid-May 2020, the United States Centers for Disease Control and Prevention (CDC) has been closely monitoring reported cases of mysterious syndrome that can be fatal.
To date, 44 states in the United States have reported cases and a total of 1,163 children and youth have been affected on October 30. 20 of them died.
“MIS-C is a new syndrome, and many questions remain unanswered as to why some children and adolescents develop it after covid-19 disease or after contact with someone who has covid-19, while others do not,” writes the CDC.
Most of the reported cases of MIS-C occur in children and adolescents between 1 and 14 years old, with an average age of 8 years.
More than 75 percent of reported cases occurred among ethnic minorities, says the CDC.
98 percent of cases (1145) tested positive for SARS CoV-2, the virus that causes covid-19.
The rest were in contact with someone with coronavirus disease.
Most children developed MIS-C two to four weeks after infection with SARS-CoV-2. Just over half (56 percent) of the reported cases were boys.
The CDC writes to parents on its website that they still don’t know what causes MIS-C.
“However, we know that many children with MIS-C had the coronavirus that causes covid-19 or were close to someone with covid-19. MIS-C can be severe, even fatal, but the majority of children who develop the syndrome improve with medical treatment ”, reassures the American Institute of Infectious Disease Control.
Some research studies on MIS-C have already been published.
The medical journal Progress in Pediatric Cardiology described the medical history of a 14-year-old boy admitted to the Nemours Children’s Health System in Delaware.
The boy, who was hospitalized with mysterious symptoms in April this year, is considered one of the first known cases of MIS-C in the United States.
There are also known cases of dangerous syndrome among children in Norway.
In August, the Journal of the Norwegian Medical Association wrote about a child with heart failure and the threat of multiple organ failure after infection with Sars-CoV-2.
This is not covid-19, but a late immune-mediated reaction called multiple organ inflammatory syndrome. We treat several children because of this, and the same is reported internationally ”, writes Tidsskriftet.
In September, the renowned The Lancet published a review article that includes 39 observational studies with a total of 662 patients.
“With a quick diagnosis and medical treatment, most children will survive, but the long-term consequences of this condition are currently unknown,” says the document.
This summer, the leading medical journal New England Journal of Medicine wrote that MIS-C in children led to serious and life-threatening illnesses in previously healthy children and adolescents.
The study was recently published in the online edition of the journal.
This study confirms previous findings that some children develop a strong inflammatory reaction in covid-19 that contributes to serious illnesses, the so-called multisystemic inflammatory syndrome in children, assistant health director Espen Rostrup Nakstad told Dagbladet.
Nakstad points out that the incidence of the syndrome is low, but that the condition is severe for the affected children.
– Therefore, it is important that such studies are complemented by several clinical studies where patients are also followed up prospectively from the moment of admission, says Nakstad.