The mysterious bacterium that "eats" Parkinson's treatment has been revealed



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<p class = "canvas-atom-screen-text Mb" (1.0em) Mb (0) – sm Mt (0.8em) – sm "type =" text "content ="US researchers have good and bad news about Parkinson's disease: the drug Levodopa (L-dopa) is mainly degraded by two bacteria-specific microbiota, making it less effective … But they have discovered a way to disable this unwanted metabolism . These works are published in the journal."data-reactid =" 22 ">US researchers have good and bad news about Parkinson's disease: the drug Levodopa (L-dopa) is mainly degraded by two bacteria-specific microbiota, making it less effective … But they have discovered a way to disable this unwanted metabolism . These works are published in the journal.

<h2 class = "canvas-atom-screen-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Intestinal bacteria digest food … And some drugs"data-reactid =" 23 ">Intestinal bacteria digest food … And some drugs

<p class = "canvas-atom-screen-text Mb" (1.0em) Mb (0) – sm Mt (0.8em) – sm "type =" text "content ="When we swallow a bite of bread, it necessarily passes through the billions of bacteria that live in the intestines and helps the body to decompose to absorb nutrients. Because some substances, such as essential fibers, can not be digested only by the human body. "But this kind of microbial metabolism can also be harmful"says Maini Rekdal, the first author of the study, in a statement, because if helping the digestion of bread is a good thing for us, there are substances we swallow and we do not want them to degrade prematurely … like drugs."The drug may not reach its target in the body, become suddenly toxic or lose effectiveness"says Maini Rekdal."data-reactid =" 24 ">When we swallow a bite of bread, it necessarily passes through the billions of bacteria that live in the intestines and helps the body to decompose to absorb nutrients. Because some substances, such as essential fibers, can not be digested only by the human body. "But this kind of microbial metabolism can also be harmful"says Maini Rekdal, the first author of the study, in a statement, because if helping the digestion of bread is a good thing for us, there are substances we swallow and we do not want them to degrade prematurely … like drugs."The drug may not reach its target in the body, become suddenly toxic or lose effectiveness"says Maini Rekdal.

<h2 class = "canvas-atom-screen-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Parkinson: levodopa is "digested" by the microbiota"data-reactid =" 25 ">Parkinson: levodopa is "digested" by the microbiota

<p class = "canvas-atom-screen-text Mb" (1.0em) Mb (0) – sm Mt (0.8em) – sm "type =" text "content ="A good example of the problems presented by this microbial metabolism is the main drug used to treat Parkinson's disease: Levodopa (L-dopa). To be effective, L-dopa must enter the brain and be converted into dopamine, a neurotransmitter that patients do not have and without which the body can suffer from tremors, muscle stiffness, and balance and coordination problems. "data-reactid =" 26 ">A good example of the problems presented by this microbial metabolism is the main drug used to treat Parkinson's disease: Levodopa (L-dopa). To be effective, L-dopa must enter the brain and be converted into dopamine, a neurotransmitter that patients do not have and without which the body can suffer from tremors, muscle stiffness, and balance and coordination problems.

<p class = "canvas-atom-screen-text Mb" (1.0em) Mb (0) – sm Mt (0.8em) – sm "type =" text "content ="However, the gastrointestinal tract is also an important site for the transformation of L-dopa into dopamine … which can no longer cross the blood-brain barrier (which protects the brain) and causes undesirable side effects, including gastrointestinal disorders. -intestinaux […]"data-reactid =" 27 ">However, the gastrointestinal tract is also an important site for the transformation of L-dopa into dopamine … which can no longer cross the blood-brain barrier (which protects the brain) and causes undesirable side effects, including gastrointestinal disorders. -intestinaux […]

<p class = "canvas-atom-screen-text Mb" (1.0em) Mb (0) – sm Mt (0.8em) – sm "type =" text "content ="Read more about sciencesetavenir.fr"data-reactid =" 28 "> Read more about sciencesetavenir.fr

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