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Endemic Bacteria of the Eyeball .. What is its function?



Know that the intestines and skin are home to a group of microbes, which are vital for health, but do you know that your eyes also harbor a unique set of microbes?

The surface of the eye is one of the most hospitable environments of microbes in mammalian bodies because tears carry antimicrobial agents; however, researchers have discovered that some microbes may live on the surface of this tissue and may play a key role in preventing ocular inflammation .

These microbes are called microbiomes (a microbial group of living microbes). When these microbes are unbalanced, with certain species more or less normal, eye diseases can occur.

A recent study found that bacteria live on the surface of the eye and stimulate its protective immunity. Scientists have begun digging deeper into microbial agents that can be used to create innovative treatments for a variety of eye disorders such as dry eyes, Schogren's syndrome and scarring or swelling of the cornea.

Immunology expert Anthony St Leger, assistant professor of ophthalmology at the University of Pittsburgh, says that someday it will be possible to design bacteria to treat eye diseases in humans and that understanding the effect of bacteria on immunity is essential to avoid a million visits. For doctors for eye infections and $ 174 million a year in the United States alone.

The researchers used mice to determine if the bacteria on the surface of the eye could stimulate an immune response to protect the eye from pathogens that lead to blindness.

Researchers have found endemic bacteria in the eye called Corynebacterium mastitidis, which stimulate immune cells to produce and release antimicrobial agents that kill their harmful pathogens.

Through a series of experiments, the researchers were able, for the first time, to show a causal relationship between Corynebacterium mastitidis and the immune immune response.

When Corynebacterium mastitidis is present on the surface of the eye, mice exhibit more resistance to two types of bacteria known to cause blindness, namely "pseudomonas aeruginosa" and "white ovulation".

St. Lager and his colleagues are now working on exploring the relationship between Corynebacterium mastitidi and immunity to develop new treatments to prevent infection and possibly target more common diseases such as dry eyes.

The first step in developing such treatments is to know how bacteria colonize the eye, in which researchers are now working in laboratories.

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