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Min Kyung-tae, professor, finds the principle of genetic functioning … "Contributing to the development of therapeutic agents"
(UNIST) researchers have identified the gene responsible for the intellectual disability of Down syndrome (DSCR1) and its principle of functioning for the first time in the world.
Min Kyung-Tae, a professor of bioscience and mathematics, used mice engineered with DSCR1 to determine the role of the DSCR1 protein in the expression of the major repressors (TET1 and miR-124 protein) in adult neurogenesis.
Adult neurogenesis is the process by which new neurons are generated in the hippocampus of the adult brain.
Degenerative brain diseases of Alzheimer's and Parkinson's, schizophrenia and Down syndrome, which are neurodevelopmental-related diseases, have been reported to have problems with adult neurogenesis.
However, the understanding of the pathological relationship between these diseases and adult neurogenesis and molecular and cytological principles is insignificant.
The team successfully restored the overexpression of DSCR1 in the mouse model with Down syndrome without learning and memory capacity and recovered the compromised adult neurogenesis and learning / memory impairment.
It is confirmed that the expression of the subsequent regulatory factor by the DSCR1 protein is the main principle of adult neurogenesis occurring in the hippocampal region and the essential principle of adult neurogical disorder in Down's syndrome.
"It will provide a fundamental understanding of the principles that control the development of hippocampal neurons in the adult brain," said Professor Min. "This study will contribute to the development of therapeutic agents capable of curing the cognitive deficits of patients with Down syndrome.
The study was published in The EMBO Journal, a world-renowned journal of molecular biology.