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If you have gastrectomy for cancer or obesity …



Problems in Meat and Dairy Absorption
Alzheimer's dementia risk up to 2.7x ↑
0.5 times more vitamin B12

If you have gastrectomy for cancer or obesity ...

Vegetarians, stomach cancer, obesity, metabolic diseases, if the stomach is partially or fully excised, vitamin B12 deficiency is likely to occur. If your body lacks vitamin B12 to produce red blood cells, nerves and DNA, nervous system disorders such as anemia, abnormal sensations and numbness of the hands, legs and feet, gait disturbances (stumbling and balance disorders), inflammation of the tongue, cognitive impairment, forgetfulness, can cause depression and delusions.

If you have a nutrient absorption disorder such as Crohn's disease, the amount of gastric acid secretion to aid in the absorption of vitamin B12 is not sufficient due to long term antacids or aging.

If so, you can continue taking or injecting vitamin B12 supplements. If the stomach is cut or gastrointestinal problems occur, the intrinsic factor that helps absorb vitamin B12 in meat, eggs and dairy products is lost or diminished. 47% of patients with dementia are deficient in vitamin B12.

In recent years, studies have shown that the risk of developing Alzheimer's dementia is up to 2.7 times higher than in the same age group among people 50 years and older who had their stomachs cut off. On the other hand, even if the stomach was excised, the risk of developing Alzheimer's dementia was only 0.5 times higher than that of the general population if vitamin B12 supplementation was continuously taken and injected.


Dr. Shin Dong-wook, professor of family medicine at Samsung Medical Center, and Dr. Yoon-Jin Choi of Seoul National University National University of Medicine, had about 64,000 patients with gastric cancer aged 50 or over. more who received gastrectomy between 2007 and 2012 using big data health insurance (80% for partial resection and 20% for all resections). The average age of 5.6 years was about 20,300 people in the same age group. The average age was 63.2 years, and they had no other cancer, history of dementia, Parkinson's disease or stroke.

The risk of developing Alzheimer's dementia in all gastric resection groups was 39% higher (30% in all dementias) than the control group. The risk of developing dementia was 1.96 times and 2.66 times higher than the general population, respectively, when vitamin B12 was not replenished after all of the above resections, or when replacement was discontinued within three years after surgery. On the other hand, the risk of developing dementia in the stomach resection group, which is constantly supplemented with vitamin B12, was 0.71 times that of the general public (0.5 times in Alzheimer's dementia).

Dr. Choi said: "Three years after all of the above resections, vitamin B12 deficiency begins to become more severe and if you do not supplement it, you should be careful about the factors that cause dementia." Professor Shin said, "Without a stomach, it is easy to lack various nutrients such as vitamin B12." Vitamin B12 requires regular observation and supplementation to prevent dementia.

On the other hand, unlike Alzheimer's dementia, the risk of vascular dementia was 23% lower in the total ablation group (14% in the partial ablation group). This is because the gastric resection group reduces the amount of food and the ability to absorb nutrients, reduces visceral fat and improves metabolic diseases indicative of vascular dementia such as hypertension, hyperlipidemia and diabetes.

The results are published in the American Journal of Oncology. By Im Woong-jae, team reporter jaelim@sedaily.com


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