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Fatty non-alcoholic liver failure leads to cardiovascular disease

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Professor Min Soo Lim of the Bundang Hospital of the National University of Seoul and Professor Thaskinen of the University Hospital of Helsinki, Finland, and Professor Boren of Salgenska University Hospital in Sweden analyzed the relationship between fatty liver and cardiovascular disease and found that fatty liver increases the risk of cardiovascular disease. Announced

Fatty liver, one of the common liver diseases, has a fairly high prevalence in 20-30% of Korean adults. Fatty alcoholic and non-alcoholic liver can be divided into two main categories: patients with non-alcoholic fatty liver disease are constantly increasing. A biopsy of more than 500 Koreans conducted by Korean researchers showed that the prevalence of non-alcoholic fatty liver disease was as high as 51%.

Fortunately, "simple greasy liver", which accumulates only fat in hepatocytes, does not pose a serious health risk. However, increased oxidative stress or increased insulin resistance caused by active oxygen during the cellular respiration process can lead to inflammation in the liver, which may eventually be exacerbated as "severe fatty liver" or "hepatitis." At the same time, fat metabolism in the liver can not be achieved without problems, arteriosclerotic hyperlipidemia is serious.

The results of the study showed that the incidence of cardiovascular disease was significantly increased in patients with non-alcoholic fatty liver disease as well as in the liver itself. The risk of cardiovascular disease was 1.64 times higher in patients with non-alcoholic hepatic steatosis compared to those without hepatic steatosis, and the risk of cardiovascular disease increased to 2.58 fold in patients with severe fatty liver deposits as well as adipocyte deposition in inflammatory cells.

"If the inflammation developed in the liver is exacerbated, it is important to break this bond as it can lead to chronic diseases such as cardiovascular disease and diabetes, as well as complications inherent in the liver, such as cirrhosis and liver cancer, he said.

According to Professor Lim, professor of endocrinology at Seoul National University Hospital, a researcher at Bundang Hospital of the National University of Seoul, "Previous studies have shown that half of people with hepatic steatosis can develop cardiovascular disease in the future.

Simple greasy liver can be improved by weight loss, low calorie diet and regular exercise, but it is very difficult to regain health when it progresses to inflammatory fatty liver disease. In addition, there is no clear remedy for fatty hepatitis, so it is important to manage it early when it is a simple fatty liver.

Professor Lim said, "Over the past hundred years, Koreans have had a low-calorie, activity-intensive lifestyle in the last few decades, but in the last 20-30 years they have switched to a high-calorie diet and physical activity has decreased as transport developed." "Because of these socioeconomic changes, the rate of hepatic steatosis is increasing rapidly, so it is very likely that complications such as cirrhosis and liver cancer lead to an increase in diabetes and cardiovascular disease."

To stop this vicious cycle and reduce the complications caused by fatty liver, it is urgent to have healthy living habits and an adequate awareness of the fatty liver from an early age. In fact, many countries around the world are paying attention to the risk of hepatic steatosis and promoting preventative policies, such as reducing fast food intake and encouraging exercise in middle and high school.

Above all, it seems that Koreans need a national policy to reduce diabetes and cardiovascular complications when it comes to fatty liver disease and 30% of people 20 years of age or older (about 10 million) suffer from hepatic steatosis. .

The study, which systematically summarizes the risks of fatty liver disease, was published in the April 2019 issue of the international scientific journal Obesity Reviews.

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