"Diabetes drug metformin, effective in left ventricular hypertrophy"


Metformin, a standard treatment for diabetes, has been shown to be effective in treating left ventricular hypertrophy (LVH) in people without diabetes.

Left ventricular hypertrophy is a phenomenon in which the left ventricle wall, which is the lower left part of the heart, pumps blood to the whole body, leading to heart failure, myocardial infarction or stroke, causing insufficient blood supply to all organs and tissues of the left ventricle. .

Hypertension, obesity and insulin resistance are risk factors and the symptoms are often not felt.

A team of researchers at the School of Medicine and Clinical Medicine at the University of Dundee conducted a 12-month study of metformin remodeling in 68 pre-diabetic patients with coronary artery disease. The results of the study (MET-REMODEL Trial) were revealed, Medical Express reported on Thursday.

Clinical trials were performed dividing the participants into two groups and the daily dose with metformin (2,000 mg) or placebo.

The results showed that the metformin group had twice as many left ventricular walls thicker than the control group.

The metformin group also had lower blood pressure and decreased oxidative stress compared to the control group, while mean body weight decreased by 3.6 kg.

Oxidative stress is a phenomenon in which active oxygen, a harmful oxygen generated in the body's metabolic process, causes damage to cells and DNA.

If this effect of metformin is confirmed in major clinical trials in the future, the researchers predicted that metformin could be remodeled for new uses.

Metformin is an inexpensive drug that has been used in the treatment of diabetes since it inhibits the synthesis of glucose in the liver and promotes the uptake of glucose into the cells, thereby lowering blood sugar.

The study was published in the latest issue of the European Heart Journal, the journal of the European Society of Cardiology.

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