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Hyperlipid diet reveals negative effects on intestinal bacteria in human experiments – GIGAZINE

Two hundred subjects were fed a diet rich in fat, medium and low fat for six months, and it was observed how the enteric bacterium changed. Although such experiments have been performed with mice in the past, few human experiments have been conducted, resulting in valuable research results.

Effects of dietary fat on the intestinal microbiota and fecal metabolites and their relationship to cardiometabolic risk factors: a randomized, 6-month, controlled-feeding study

A diet high in fat may be bad for your intestinal bacteria

In this study, a six-month experiment was performed on 217 healthy men and women aged 18-35 years. In the experiment, subjects were divided into three groups: "low fat diet" with 20% of total calories in the first group and "medium" with 30% of total calories in the second group. In the third group, 40% of the total calories received a high-fat diet for the third group, and it was examined how the diet would alter intestinal bacteria, fecal metabolism, etc. .

As a result, the researchers said that "individuals on a high-fat diet had" unfavorable changes "in the level of certain bacteria and substances produced by bacteria. The change is likely to increase the risk of metabolic diseases such as type 2 diabetes , long-term.

Foods have become westernized in China and other parts of the world, but the results of this study are relevant not only to these areas but also to Westerners who eat diets that are inherently greasy. You However, this experiment was performed on relatively young individuals, and the effects on the elderly are still unclear. The research team needs to do more research in the future.

by Joenomias

Previous studies have shown that diets high in fat increase the risk of cancer, especially colon cancer, in experiments with mice. There have also been studies that investigated the relationship between high fat diet and intestinal bacteria in experiments with mice, but few experiments in humans were conducted.

Results of a high-fat diet increase the risk of colon cancer-GIGAZINE

The present study is characterized by the fact that the experiment was conducted by feeding a hyperlipidic diet to humans, and although the amounts of fat and carbohydrate were established beforehand to be different in each group, the amounts of protein and vegetable fiber were All three groups were the same. Researchers identified the impact of eating habits by analyzing blood samples and faeces submitted by participants at the beginning and at the end of the experiment.

More specifically, the group that continued to take a low-fat diet after the experimentBlautierOrFicalibacteriumSuch bacteria, which are generally called "good bacteria", have been increased in comparison with the beginning of the experiment. On the other hand, the group that continued to eat a high-fat diet said that these bacteria decreased. Blautia and Ficalibacterium are important sources of energy for enterocytes and have anti-inflammatory activityButyric acidResearchers explain that this helps to generate In fact, butyric acid contained in feces is said to have increased in the low-fat group and decreased in the high-fat group.

In addition, high fat groupBacteroidesOrAristipesIt has also been confirmed that the bacteria that appear to be related to type 2 diabetes are increasing. In addition, the level of long chain fatty acids believed to cause an inflammatory response is increasing, and it is also confirmed that the level of inflammation in the blood is actually increased.

The researchers concluded that taking a high-fat diet over time seems to have a negative impact compared to a low-fat diet.

from Luis Reynoso

In addition, weight loss was confirmed during the period in all subjects in the 3 groups, and in particular, the body weight of the low-fat diet group was the largest. It is not yet clear whether weight loss is associated with changes in intestinal bacteria, and researchers have stated the need for more research.

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