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An Italian study is launched to assess whether calorie restriction and the elimination of certain foods from the diet can improve the symptoms and effectiveness of therapy
Reduce daily calories and eliminating some diet foods can slow the course of multiple sclerosis? If they ask two Italian research groups the Federico II University of Naples and the IRCCS Santa Lucia Foundation in Rome, who are starting a clinical study funded by the Italian Multiple Sclerosis Association (AISM) and its FISM Foundation.
Where does this hypothesis come from?
Just over ten years ago, a team of experts found that high levels of leptin, a hormone produced by adipose tissue to regulate energy expenditure and the sensation of satiety, can reduce the capacity of the body. regulatory T cells to maintain the proliferation of self-reactive T cells, who are directly involved in the onset of multiple sclerosis. The leptin values increase mainly due to the abundant consumption of animal fats and sugar, therefore, a high calorie diet can inhibit the proper functioning of cells that normally protect against this neurodegenerative disease. In addition, according to the results of another research, leptin is more present in people with multiple sclerosis than in healthy people. Starting from these premises, the research groups from Naples and Rome will try to understand if the calorie restriction can manipulate immunity and affect the functionality of the immune system.
For this study, which will provide experts with the first results as early as 2020, 100 people with multiple sclerosis will be involved, undergoing the same therapy. A part of them will follow, for a whole year, a diet with the 15-20% less daily caloric intake in comparison with the current one. After 12 months of experimentation, the effects of this change will be compared to a control group by magnetic resonance imaging and Expanded Disability Status Scale (EDSS). Finally, another group will make a personalized diet without certain foods responsible for abnormal immune reactions such as: milk derivatives it's the gluten. Also in this case, the researchers will evaluate the impact of diet on the response to therapy and on the course of the disease in general.
The comment of prof. Giuseppe Matarese
Nutrition, immune system and multiple sclerosis: this correlation speaks to our microphones Giuseppe MatareseProfessor of General Pathology and Immunology, Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples Federico II.
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