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More and more young at risk for Alzheimer's disease, 10% of cases are under 65

Alzheimer's disease is the most common form of degenerative dementia that progressively affects brain structures. But despite the higher-risk elderly, there is an increase in the appearance of young forms. If, in fact, the onset of the pathology is mainly completed in old age, over 65, it is increasingly common to occur earlier: 5-10% of all cases concern people under 65; with the possibility, in cases of dominant genetic disease, that their children may inherit from the parent the part of the DNA that generates the disease, beginning between 35 and 60 years. For this reason, it is good to know the symptoms of their initial form.

"Juvenile-onset Alzheimer's disease mainly includes familial forms that exhibit noticeable impairment of episodic memory – explains Salvatore Cuzzocrea, a professor of pharmacology at the University of Messina – compared to Alzheimer's patients, people with early Alzheimer's are less affected by cerebrovascular, renal and cardiac diseases. Even though the minimum common denominator is the same, among the clinical characteristics of patients with juvenile disease, we find executive function deficits and verbal production deficits, which are associated with short-term memory loss. Some patients have a significant impairment in the visual process of object identification and perception.». In this context, an early diagnosis is therefore very important, with the possibility of opening to pharmacological treatments capable of delaying the onset of the disease.

"Numerous evidence today shows an association between neurodegenerative diseases, in particular Alzheimer's disease, and neuroinflammation that may begin some time before a significant loss of neuronal population occurs – the expert explains. – The neuroinflammatory process is characterized by interactions of the immune type that determine the activation of microglia, astrocytes, central nervous system resident mast cells, cytokines, chemokines and related molecular processes. Activation of this pool of non-neuronal cells represents the true cause of degenerative neuron damage.».

Controlling brain neuroinflammation can therefore preserve memory in people with Alzheimer's.

"The appearance of neuroinflammatory phenomena is therefore a first alarm and, at the same time, a window of time to start acting. modulate the action of non-neuronal cells and the effect of oxidative stress, improving patients' cognitive functions and behavioral disorders. From this, it is concluded that modern therapeutic intervention should focus on drugs capable of neutralizing neurodegeneration by modulating the activation of non-neuronal cells residing in the central nervous system.».


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