Mutation leads to extremely rapid wound healing in the patient


How to protect a mutation from pain, sores and fears

A Scottish retiree seems to have a lot in common with the superheroes of the current Marvel films. The old lady hardly feels any pain and has an extremely strong ability to heal wounds. Researchers have now discovered that the woman's extraordinary ability is due to a mutation.

A recent study from University College London and the internationally respected University of Oxford found that the 71-year-old woman in Scotland has virtually no pain from a mutation and can heal wounds very quickly, often without scars. The results of the study were published in the British Journal of Anaesthesia.

Scars usually leave scars on our body. A Scottish old woman suffers from a mutation, so she feels little pain and heals wounds without scars. This could in the future lead to a new way of treating pain and sores. (Image: gamjai /

Woman noticed burns mainly only by smell

The sufferer reported numerous burns and cuts without pain. She often smelled burnt flesh before she noticed the injury. The pain and the superhuman cure are, according to the researchers, due to a genetic mutation previously not described. The case may open the door to a host of new treatments that help people recover better after surgery and overcome the chronic pain and anxiety disorders.

Researchers became aware of hip replacement mutation

Jo Cameron attracted the attention of doctors for the first time when she was treated for a hip problem at age 65. The hip was later classified as arthritic and had to be replaced. The patient did not respond as expected to the debilitating procedure and after a second painless surgery, the doctors decided that the case should be examined more closely.

Wounds usually healed without scars

In addition to his detailed medical history, the patient reported numerous burns and cuts without pain. The resulting wounds or burns healed exceptionally fast and there was only a very small scar or no scar. The old lady did not realize she was so different from other people until she needed a hip prosthesis. Until a few years ago, the woman simply had no idea that it was unusual to feel so little pain. The affected person was of the opinion that this was completely normal.

FAAH-Out closes an important gene in the patient

In their study, researchers from University College London and the University of Oxford identified two notable mutations in the patient. One mutation was a gene called FAAH (fatty acid amide hydrolase). The FAAH gene plays a role in the body's endocannabinoid system, parts of the central nervous system that play an important role in pain, memory and mood, and in which compounds in cannabis act. They also found a second gene that was previously considered DNA without any useful purpose. It now appears that this gene, called FAAH-Out, controls the Faah gene and isolates it in MRS. Cameron.

Patients were not afraid and never panicked.

In addition to increasing wound healing and resistance to pain, the woman has achieved exceptional results in tests of anxiety and depression. She explained that she never panics in dangerous situations, such as a car accident.

Insights Could Protect People From Pain In The Future

The effects of these findings are immense, explain the authors of the study. Half of the patients who have recovered from surgery still have moderate to severe pain despite modern painkillers. The so-called FAAH-out could be the key to releasing the potential for pain reduction of the FAAH gene if other treatments had already failed. The results suggest a new analgesic finding that may provide relief from postoperative pain and may also accelerate wound healing. The new findings are expected to help 330 million patients undergoing surgery worldwide each year, according to the research team. The old lady was thrilled that her genetic mutation could help other people who suffer. (THE)


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