The accident happened around 06:00 between Strančice and Svojšovice.
"There was only one man in the car, the impact did not survive," Svoboda said.
"Of the causes still unknown, the driver of a passenger car crashed into a pillar of the bridge. Currently, the entire event is being investigated on the spot, "added Veronika Čermáková, a police spokeswoman.
The road was closed for rescue and accident investigation.