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Discovered a new antibody for the treatment of motor neuron disease – superoxide, applied, super, muscular atrophy, also called – Technology Daily



2018-12-11 01:07:20 Source: Technology Daily


Science · Transformation Medicine
2018.12.5

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the presence of abnormal forms of proteins, such as superoxide dismutase 1 (SOD1), which accumulate in neurons and degenerate to death. Researchers at the Institute of Regenerative Medicine at the University of Zurich, Tobias Welt, extracted a human antibody from a healthy group of elderly people who recognizes the superoxide dismutation in the spinal cord tissue of patients with amyotrophic lateral sclerosis. Enzyme 1 is abnormal. When applied to an animal model of amyotrophic lateral sclerosis, the antibody may delay the occurrence of sports injuries, prolong the survival time of the animal, reduce neuronal degradation, and accumulate superoxide dismutase 1 aggregates. These results indicate that this antibody has potential value in the treatment of amyotrophic lateral sclerosis involving incorrect folding of superoxide dismutase 1.





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