Sunday , October 24 2021

They find an order in the chaos of melanoma


EFE / Madrid

Melanoma is one of the most aggressive tumors and, from the earliest stages, may result in metastasis, which occurs in a seemingly catholic manner with the involvement of many processes. Now a group of Spanish researchers have managed to find an order for this chaos.

Specifically, scientists from the Melanoma Group of the Spanish National Center for Cancer Research (CNIO), led by Marisol Soengas, have shown that metastatic processes do not occur through independent mercenaries but are coordinated by a general captain: the p62 protein. .

That is, numerous processes involved in melanoma metastasis, which until now are created independently of each other, have a global coordinate which is the p62 protein mentioned above.

According to this study, one of the proteins controlled by p62 is FERMT2, explains the CNIO, a press release, in which it is recalled that this had not previously been related to melanoma metastasis.

The work shows that both FERMT2 and p62 could become a prognostic marker of disease progression in patients.

To reach their conclusions, scientists have done a thorough study with the most advanced bioinformatics technologies and have achieved a detailed characterization of p62 and all the processes in which it is involved in melanoma.

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