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Researchers link air pollution in Mexico City with the development of Alzheimer's disease


Posted 12/26/2018 5:52:58 PMCET

MADRID, December 26 (EUROPA PRESS) –

O Environmental pollution in Mexico City is associated with the development of Alzheimer's disease in children and young adults, according to a study completed by the universities of Montana, Valle de México, Boise State, Veracruzana, the National Institute of Pediatrics of Mexico, the Paul-Flechsig Institute of Brain Research and the German company Analytik Jena published in & # 39; Journal of Alzheimer's & # 39; s & # 39; s. Disease

Mexico City is an example of extreme urban growth and severe environmental pollution. In it, millions of children are exposed throughout life and unintentionally to concentrations of air pollution well above current US standards, including fine particles 2.5, those with less than 2.5 microns in diameter.

The scientists identified the evolving axonal damage using a new judgment in cerebrospinal fluid. The study focused on 507 normal samples of cerebrospinal fluid from children, adolescents and young adults in Mexico City and controlled them with cities with low levels of pollutants in the air.

They used a Non-phosphorylated high affinity tau protein monoclonal antibody as potential Alzheimer's biomarker and axonal damage. In 81 samples, the researchers also measured total tau protein, threonine-phosphorylated tau, beta-amyloid 1,42, brain derived neurotrophic factor, insulin, leptin, and inflammatory markers.

The authors documented myelin axonal size and Alzheimer's disease with nanoparticles derived from the combustion of highly oxidants in the white matter of the anterior cingulate cortex in six samples of young people living in Mexico City and with two controls.

The unphosphorylated monoclonal antibody of tau protein significant increase with age, an important finding in the young population where axonal changes are already present and the hallmarks of Alzheimer's disease are constantly evolving in the first two decades of life.

A 2015 study has already found 138 percent more Alzheimer's risk if the 4.34 micrograms per cubic meter in 2.5 fine particles is exceeded and if exposure to them, besides an ozone above standards, is prolonged.

The researchers evaluated that efforts should be targeted to identify and mitigate environmental factors that influence the development of Alzheimer's disease and that the neuroprotection of children and young adults should be a public health priority to halt the development of the disease in the first two. decades of life.

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