The researchers developed a calculation model for five types of infections based on data from the European Antimicrobial Resistance Surveillance Network (EARS).
By 2015, they estimated the number of people infected at 671,689 and the number of deaths attributable to multiresistant bacteria at 33,110.
The impact is "comparable to the cumulative effect of influenza, tuberculosis and the Aids virus" in the same period, according to the authors.
Most deaths affect children under the age of 12 and those over 65.
The impact in terms of mortality is higher in Italy and Greece (the first concentrates more than a third of the deaths), according to the study.
The medical sector is constantly on the alert about the danger of excessive or inadequate use of antibiotics, which makes bacteria resistant to them.
An Australian team highlighted in September the dangerous spread of resistant bacteria to all existing drugs, Staphylococcus epidermidis, which can cause serious illness and even death, and is related to methicillin-resistant Staphylococcus aureus (MRSA).
Of the 671,689 infections caused by a multidrug resistant bacterium in 2015, about two-thirds were contracted in the hospital setting.
Researchers emphasize the "urgency of considering resistance to antibiotics as a vital fact for health" and "the need to plan alternative treatments for patients with other diseases and who are more vulnerable due to the weakening of their immune defenses or their age ". .