Saturday , October 23 2021

Mexico-US Research Identifies Gene in Mexican Population


A genetic study conducted by a Mexican-American scientific consortium has identified a gene present in mestizos and indigenous peoples of our country that can develop MODY (Diabetes of Early Childhood Maturity), which manifests at age 45 in people who are not usually obese and need insulin soon enough.

In the first part of the investigation DNA samples were collected from more than 8,000 Mexicans, half of them based in Mexico City and another in Los Angeles, California; In the second stage, just over four thousand citizens participated, with a proportion of 75% in the capital of the country and the remainder in the city of California.

This large study was sponsored by the SIGMA Consortium (Slim Initiative in Genomic Medicine of the Americas), which integrates researchers from Large institute (from Harvard University and the Massachusetts Institute of Technology), the National Institute of Nutrition Salvador Zubirán and the Institute of Biomedical Research of UNAM, Mexico.

"It took a long time to collect the samples and, based on genetic information plus clinical data, look for the variant among millions of generated data. Once we had them, all the DNA was sequenced and it took us a year to process the information and infer which would be the needle in the haystack, "says Mexican scientist Karol Estrada, a researcher at the Analytical and Translational Genetics Unit at Massachusetts General Hospital. and in the Large institute in Boston.

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