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Mannose sugar may improve cancer treatment

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Updated 11/23/2018 – 10:44

Key words:cancer, treatment, sugar, mannose, improve

Cancer Cells – Archive

London, 23/11/2018 (The People Online) Some natural supplements, such as mannose sugar, can be of great help in the treatment of cancer. According to the results of a study, funded by Cancer Research UK and Worldwide Cancer Research, published today in Nature, this nutritional supplement appears not only to slow tumor growth but also to improve the effects of chemotherapy in rats with multiple types. of cancer, says ABC.

Tumors are known to use more glucose than normal, healthy tissues. However, it is very difficult to control the amount of glucose in your body just with diet. In this study, the researchers found that mannose can interfere with glucose to reduce the amount of sugar that cancer cells can use.

Professor Kevin Ryan, lead author of the Beatson UK Cancer Research Institute, says, "Tumors need a lot of glucose to grow, so limiting how much they can use should slow the progression of cancer. In our study, we found a dose of mannose that could block glucose enough to delay tumor growth in mice, but not so much that normal tissues were affected. but it is hoped that finding this perfect balance means that in the future, mannose can be given to cancer patients to improve chemotherapy without undermining their overall health. "

Tumors need a lot of glucose to grow, thus limiting how much they can use should slow the progression of cancer.

In their study, researchers first examined how mice responded with pancreatic, lung or skin cancer when mannose was added to drinking water and given as an oral treatment. And they noted that the addition of the supplement significantly reduced the growth of tumors and caused no side effects.

To test how mannose might affect cancer treatment, rats were treated with cisplatin and doxorubicin, two of the drugs most commonly used in chemotherapy. They found that mannose improved the effects of chemotherapy, slowing tumor growth, reducing tumor size and even increasing the life span of some mice.

Similarly, other types of cancer have been investigated, such as leukemia, osteosarcoma, ovarian and bowel cancer. The researchers cultured cancer cells in the laboratory and treated them with mannose to see if their growth was affected.

Some cells responded well to treatment, while others did not. The presence of an enzyme, which breaks mannose in cells, was also found to be a good indicator of treatment efficacy.

Mannose is sometimes used for short periods to treat urinary tract infections, but its long-term effects have not been investigated. It is important that more research is done before mannose can be used in cancer patients.

In that sense, Martin Ledwick of Cancer Research UK believes that while these results are very promising for the future of some cancer treatments, "this is a very old research and has not yet been tested in humans." Patients should not self-prescribe mannose as there is a real risk of negative side effects that have not yet been tested. It is important to see a doctor before you dramatically change your diet or take new supplements.

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