Thursday , October 21 2021

Gene identification in Mexicans that allows the development of diabetes MODY



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The Mayan journey
Photo: Agency ID

Mexico City
Monday, December 24, 2018

A genetic study conducted by a Mexican-American scientific consortium has identified a gene that is present in mestizos and indigenous peoples of our country who can develop MODY (Diabetes of Early Childhood Diabetes), who manifests at age 45 in people who they generally do not are obese and require the use of insulin soon.

In the first part of the investigation DNA samples were collected from more than 8,000 Mexicans, half of them based in Mexico City and another in Los Angeles, California; In the second stage, just over four thousand citizens participated, with a proportion of 75% in the capital of the country and the remainder in the city of California.

This large study was sponsored by the SIGMA Consortium (Slim Initiative in Genomic Medicine of the Americas), which integrates researchers from the Broad Institute (Harvard University and the Massachusetts Institute of Technology, USA) of the National Institute of Nutrition. Salvador Zubirán and the Institute of Biomedical Research of the UNAM, by Mexico.

"It took a long time to collect the samples and, based on genetic information plus clinical data, look for the variant among millions of generated data. Once we had them, all the DNA was sequenced and it took us a year to process the information and infer which would be the needle in the haystack, "says Mexican scientist Karol Estrada, a researcher at the Analytical and Translational Genetics Unit at Massachusetts General Hospital. and at the Broad Institute in Boston.

The research was published in the Journal of the American Medical Association, where it reported that the mutated SLC16A11 gene occurs in 30% of the mestizo population and up to 50% of Mexican natives.

MODY diabetes usually occurs in a young population, and the patient arrives at the clinic and receives treatment as if it were type II diabetic. Its prevalence in Mexico is not known, and few countries have records of its presence, because to identify this type of diabetes it is necessary to do a study of the whole family.

"If there was a DNA genetic test, the type of diabetes could be determined in minutes, and based on that, the treatment to be followed, with the correct dose of the treatment to improve the patient's condition."

"In the second part of the international study we are working on a genetic diagnostic tool that costs less than 100 pesos and now does not exist. To achieve this, it is easier for us to know that it is a single gene variant for the Mexican population and you do not needs to do tests for many other genes, "says Dr. Karol Estrada.

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