The research, which obtained promising results in laboratory tests, was presented this week by its authors at the Image Foundation of Chile, in which they emphasized that the formula so far behaved very safely.
The group is formed by Felipe Oyarzún and Marcelo Kogan of the Faculty of Chemical and Pharmaceutical Sciences, and Andrew Quest of the Faculty of Medicine, who for several years has been working on the development of nanoemulsion, which consists of a mixture of fatty substances. and water, similar to milk.
The nanoemulsion reached its target in 100% of the animals treated in the laboratory with only one dose, while 70% of those who did not receive it again had cancer manifestations, they emphasized.
The researchers were interested in turmeric, a plant native to Asia to which they attributed different healing properties due to these characteristics and their low price.
"One of the most important advantages of this formula is that it takes advantage of the anti-cancer and anti-inflammatory properties of this substance, which are not adequately achieved by simply consuming turmeric because of its water insolubility, malabsorption and instability," he said. Felipe Oyarzún.
Researchers used curcumin by including it in nanovols to ensure its dissolution, correct protection and promotion of its therapeutic effect, which allowed a prolonged protection of the substance once administered in animal patients.
According to Felipe Oyarzún, curcumin is a fragile and very unstable molecule and when administered without it, it does not cause the desired effect, it can quickly destabilize.
"Within the nano-vehicle he is protected for much longer," he said.
Another significant advance of the work has been the confirmation of the safety and innocuousness of the formula when applied in doses superior to those necessary to inhibit the reappearance and metastasis of tumors, which was found in laboratory tests.
In one, a tumor extracted for treatment received a 25-fold higher dose than the initial one and we evaluated whether there was any indication of toxicity if the biochemical parameters in the blood or blood gas parameters were altered, and there was no effect, said Oyarzún.
That is, he stressed that the formulation, even in much larger doses, is equally safe, which opens the possibility of administering high doses in more complex and advanced stages of the disease.
Constanza Cea, executive director of Imagen de Chile, highlighted the potential of Chile to contribute in the field of health.
"Generating a possible solution for cancer metastasis in Chile is a tremendous contribution that shows how in our country we can contribute to a disease that afflicts people all over the world," he said.
As this formulation can be turned into powder and reapplied after being mixed with water, it is easy to transport it to distant places at an affordable cost, as well as discovering that dehydration has a longer preservation time.
The work of ACCDiS is part of the work of scientists from the University of Chile and the Catholic University who study chronic diseases with higher prevalence in Chile and abroad, such as cardiovascular diseases and cancer. EFE