Indian Services Minister Jane Philpott was chosen to fill the vacancy of office as chairman of the Treasury Board, CBC News reported.
Prime Minister Justin Trudeau will shake his office on Monday morning, probably the latest change before Canadians reach the polls later this year.
Liberal sources also said that Veterans Affairs Minister Seamus O & Regan would be transferred to replace Philpott.
The move was prompted by a top-level resignation from Trudeau's front seat.
Former PM and Treasury chairman Scott Brison announced on Thursday that he will not run for re-election this year and is leaving the position now, leaving an empty chair on the cabinet table.
Trudeau would not say whether he is simply looking to replace Brison or to plan a major change with several ministers swapping chairs.
"Obviously this will require some changes in our office," he told reporters earlier this week in Kamloops, BC.
Indications are that the scrambling will be relatively minor – though it does seem to include new faces in the Indigenous Services and Veterans Affairs.
The role of the Minister of Indigenous Services was introduced in 2017, when the Trudeau administration tried to increase the momentum in reconciliation with indigenous peoples. Philpott has been generally welcomed and respected by First Nations groups in this role, and is widely seen as a strong interpreter in the Cabinet.
As chair of the Treasury Board, Philpott will be responsible for government tax operations and oversight of the federal public service. She currently serves as the vice chair of the Treasury Board's cabinet committee.
Its movement will likely trigger a domino effect, as its old role needs to be filled, along with the enhanced representation of Atlantic Canada.
No minister from Nova Scotia
Brison's departure also means that the Cabinet is devoid of representation of Nova Scotia. There are several options for deputies from the province's backbench to fill that hole, including Sean Fraser, who is the current parliamentary secretary of Environment Minister Catherine McKenna.
Several ministers have been jugglers just six months ago, when Trudeau expanded and changed his cabinet before the election year.
The July scramble brought five new ministers to the table and added new files for seniors, intergovernmental affairs and border security.
Several portfolios, including the environment, immigration and natural resources, have proved challenging in the past year as carbon tax, border crossings and pipelines polarized voters across the country.
CBC News will take the oath live from 8 am ET, and the oath ceremony will begin at 8:45 am at the governor's general residence at Rideau Hall.