Wednesday , April 21 2021

Dad praises landmark peanut study proving that you can build a tolerance to allergies



New research has found that it is possible to build tolerance for peanut allergies.

Parents praised the historical study, which found that participants generally unable to tolerate exposure to up to a tenth of the allergen could eventually cope with two whole peanuts.

Children who suffered from a severe allergy participated in the one-year study, where they received increasing amounts of peanut protein.

Already used to treat pollen, immunotherapy therapy treatment is expected to protect people from life-threatening reactions, reports the Mirror.

Emily Pratt built a tolerance
Emily Pratt built a tolerance

The mother of a six-year-old girl who participated in the trial said it "completely changed their lives."

Sophie Pratt said, "Before Emily participated, we were uncomfortable for being more than twenty minutes from a hospital and she could not attend parties or parties without me or my husband being there.

"We had to constantly study food labels to ensure that the peanuts were completely eliminated from Emily's diet.

His allergy was very severe, so even a small amount of peanut can lead to a very serious reaction. The impact on our family life was enormous. "

The 44-year-old said that by the end of the one-year trial, Emily was able to tolerate about seven peanuts.

The PALISADE study recruited nearly 500 children ages four to 17 from the US and Europe to participate in the largest test of peanut allergy treatment.

Participants were divided into groups that received either a peanut protein capsule or a dummy powder.

Doses were gradually increased every two weeks for a period of six months, before continuing with a "maintenance dose" of peanuts for another six months.

The results, published in the New England Journal of Medicine, found that about 67% of children and adolescents could tolerate at least 600mg of peanut protein, compared with only 4% of placebo participants.

The study gave parents hope
The study gave parents hope

Professor George du Toit, a pediatric allergy consultant at Evelina London and lead investigator for the study, said: "Peanut allergy is extremely difficult to manage for children and their families, as they need to follow a strict peanut-free diet.

"Families live in fear of accidental exposure, as allergic reactions can be very serious and can even lead to death.

"Until recently, there was nothing to offer peanut allergy but education around peanut prevention and recognition and self-management of allergic reactions."

Peanut allergy, a potentially fatal condition, has doubled in the past two decades and affects about 1 in 50 children in the UK.

Allergy is rarely overcome and is the most common cause of food allergy deaths.

The PALISADE study was funded by Aimmune Therapeutics, which manufactures the peanut protein used during the study, and conducted by researchers from Evelina London Children's Hospital and King's College London.

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