Japanese researchers have injected so-called "iPS" stem cells into the brain of a patient with Parkinson's disease. This clinical trial aims to test whether these cells can regenerate dopamine neurons and alleviate symptoms.
The team atinjected 2.4 million of these , capable of giving any type of cell in the left part during a three-hour operation last month. The man, in his early 50s, was well tolerated and kept under surveillance for two years, Kyoto University said in a statement.
If no problem emerges in the next six months, researchers will deploy another 2.4 million cells, this time in the right part of the patient's brain. These iPS cells from healthy donors are expected to growdopamine, a neurotransmitter involved in motor control.
In July, Kyoto University announced the completion of this clinical trial with seven participants aged 50-69 years. "I greet patients for their courageous and determined participation", commented Professor Jun Takahashi, quoted on Friday by NHK's public television channel.
Pluripotent cells to generate new neurons
Ois marked by the degeneration of dopaminergic neurons and results in which progressively worsen, such as tremors, limb stiffness and decreased body movements. It affects more than ten million people around the world, according to USA. Therapies currently available "It improves symptoms without delaying the progression of the disease"explains the foundation.
This test follows an experiment carried out on monkeys withof human origin that have improved the ability to make movements in suffering from Parkinson's disease, according to a study published at the end of August 2017 in the scientific journal nature. The survival of the grafted cells by injection into the primate brain was observed for two years, without .
O(iPS for induced pluripotent stem cells) are adult cells brought back to the almost embryonic state, causing them to express four (usually inactive in adult cells). This genetic manipulation gives them the ability to produce any kind of (pluripotency) according to the body location where they are then transplanted. The use of iPS cells presents no fundamental ethical problems, as opposed to stem cells withdrawn human beings.
What to remember
- Scientists at Kyoto University injected 2.4 million pluripotent cells into a patient's brain.
- These cells from healthy donors will need to regenerate dopamine neurons.
- In total, the clinical trial should involve seven patients.
Parkinson: Stem cells reduce disease in monkeys
Article from Tokyo – AFP published on February 25, 2012
Monkeys developing the equivalent ofshowed an improvement in their symptoms after the injection into their brains of human stem cells. The technique could be tested in humans from 2015.
Monkeys suffering from Parkinson's disease have made significant progress after implanting human stem cells into their brains, Japanese researchers said on Wednesday.
Four monkeys whose limbs moved spasmodically (a common symptom ofin And who fought to control their bodies showed signs of improvement three months after the operation, said Jun Takahashi, a professor at the University of Washington. , one of the authors of the study published in .
Six months after theThe four primates tested were again able to walk in their cage, he added.
Jun Takahashi stated that, at the time of implementation, 35% ofwere dopaminergic neurons, and about a tenth of them were still alive a year later. In order to improve the effectiveness of treatment, he would like to increase that survival rate to 70%. He hopes to be able to conduct this experiment in humans by 2015. " We must first increase the number of dopaminergic neurons to in order to reduce the risk of " , He explained.
Induced pluripotent stem cells in humans
In this ape experience, Jun Takahashi and his team usedbut in the case of medical experience, the researchers think they are using (IPSCs), created by the implantation of four types of genes in human skin cells for reprogramming. These induced iPSCs thus generated return almost to the embryonic (undifferentiated) stage.
The use of, which is considered very promising by many scientists, opposes. Religious groups consider the culture of these cells unethical, emphasizing that . In Japan, however, nothing prohibits the use of these cells for scientific research.
Ois one of the main after . It is also one of the most common causes of motor incapacity after cerebrovascular diseases.