Wednesday , October 20 2021

Muco: She dies after transplanting a smoker's lung



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Summary: A cystic fibrosis patient dies of cancer after receiving the lungs of a woman who smokes a packet of cigarettes a day for 30 years. Doctors demand more "precautions."



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A patient with cystic fibrosis developed cancer in France shortly after transplanting a smoker's lungs, according to a study published in the journal Lung cancerwhich warns of the risk of transplanting such organs.

One package per day for 30 years

The patient was followed from childhood by cystic fibrosis. After a rapid deterioration of their respiratory functions, typical of cystic fibrosis, doctors decided in November 2015 to perform a lung transplant. "According to the donor database, the transplanted lungs were taken from a 57-year-old woman who smoked packs a day for 30 years," says the study, conducted by doctors at the University Hospital of Montpellier. She says the tests performed at the time of the donor's brain death did not reveal any abnormalities.

Cancers caused by smoking

In June 2017, the grafted patient, sick, is admitted to a unit of thoracic oncology at the university hospital of Montpellier. Two months later, she died of lung cancer without any attempt at therapy. According to the study, the symptoms strongly resemble those of cancer caused by smoking. "The small delay between lung transplantation and the appearance of the first radiological abnormality suggests that carcinogenesis began during the life of the donor, add the authors of the works. A cancer whose growth would have been greatly accelerated by the immunosuppressive treatments that the patient followed to avoid the rejection of his new lungs.

According to Dr. Jean-Louis Pujol and his colleagues, "Given the relatively long latency of lung cancer, we suggest that transplants of smokers (or newly inmates) be considered with caution. "

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