a memory deficit may appear from the twenties


Is it possible to detect early signs of Alzheimer's disease, ie memory problems, in young people with a family history? This is what advances a new study published in the journal eLife. Led by researchers at the Translational Genomics Research Institute (TGen), a subsidiary of the City of Hope, and the University of Arizona, it states that people at high risk of developing Alzheimer's disease because of backgrounds families may have memory deficits from the age of twenty.

Decreased learning performance

Affecting approximately 900,000 people in France, Alzheimer's disease is an age-related neurodegenerative disease that affects brain function, particularly memory, attention and language. The most common form of age-related dementia, Alzheimer's disease is still, at present, an incurable disease. Hence the need to better detect the early indicators of the disease to prevent dementia in people at risk, even though they are still young.

"In this study, we show that family history is associated with a decline in learning performance associated with twinning up to four decades before the typical onset of Alzheimer's disease," says Dr. Matt Huentelman, a professor of neurogenomics at TGen and lead author of this study.

Initial indications for better care

The work he did covered 59,571 participants aged 18 to 85 by the time they started in 2013. Data were collected using an online word pair memory test called MindCrowd. , one of the most important scientific assessments in the world of healthy brain functioning.

By analyzing the data collected, the researchers found that people with a family history of Alzheimer's disease and under 65 did not perform as well as their peers. Among those at highest risk are men, as well as people with low levels of education, people with diabetes or carriers of a genetic variant of ApoE, a gene associated with disease risk. Alzheimer's disease.

"This study supports recommendations emphasizing the importance of adopting a healthy lifestyle and treating diseases such as diabetes," said Dr. Joshua Talboom, co-author of the study. "Our findings particularly highlight the positive effects of such interventions for those with a family history of developing Alzheimer's disease, paving the way for the development of more risk-reducing approaches to fighting the disease." he concluded.

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