Slow progression of dementia and ALS with a drug used against mad cow disease



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Chilean scientists celebrate obtaining results "positive" in an attempt to delay the progression of diseases such as amyotrophic lateral sclerosis (ALS) and the insanity. They did this in mice using substances capable of slowing the progress of neurodegenerative diseases such as those mentioned.

The works are developed at the Millennium Institute of Biomedical Neuroscience (BNI), Faculdade de Medicina do University of Chile, in alliance with Giovanna Mallucci, PhD in Neurogenetics University of London

Dr. Claudio Hetz, who leads the team, said that Mallucci began using drugs to "manipulate the action of proteins in the brain" and discovered "its positive effects against Alzheimer's disease and mad cow disease"In his work, Mallucci searched for more than 1,000 compounds and identified that two of them could reach the brain without generating toxicity.

For now in mice, but with high potential

These investigations are currently being developed in mouse models and cell culture in order to be taken for future application in patients. Paulina Torres, a member of the team, said: "While investigations they are still very preliminary, we conducted trial evaluations, and found that the drug has the potential to prevent the progression of diseases like ALS and dementia in animal models. "Measures include cognitive and motor tests, which analyze the ability to" remember objects and coordination, "he explained .

According to Claudio Hetz, the team's expectations are "high"Considering the advantage of working with drugs that have already been used in other studies, which makes it easier to use in clinical trials. pathological aging As an important risk factor, it is possible to improve the health and quality of life of the elderly, which implies "increasing people's health expectancy, which could even make them live much longer and with a better quality of life in the coming years. decades. " "

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