Monday , October 18 2021

Broccoli compounds may prevent the development of cancerous tumors


Mexico, May 17 (Notimex) .- A group of international researchers found that existing compounds in broccoli and Brussels sprouts are capable of blocking cancerous tumors.

Pier Paolo Pandolfi, a Harvard Medical School professor of medicine and pathology and the study's lead author, has identified a compound called I3C that grows within the body and prevents the development of tumors.

According to information from the educational institution, the work was based on the function of a cancer suppressor gene called PTEN, one of the most important tumor suppressors in the history of the genetics of this disease.

According to Harvard University, this gene is usually attacked by cancers, which seek to eliminate it, mutate it or inactivate it.

Experts, who used human cells and mice to develop prostate cancer, found that an enzyme called WWP1, which promotes cancer growth, was very important to interfere with PTEN function.

The study, published in the journal Science, could allow the development of drugs based on the suppression of WWP1 and the release of PTEN to achieve results.

It can also help people with a genetic deficiency of PTEN that makes them prone to develop cancer as well as cause developmental defects that can lead to intellectual disability or psychiatric illness.

"We believe this class of drugs can be very important for human health besides cancer," Pandolfi said.

The protective compound of PTEN, I3C, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower, among others.

The specialist pointed out that further analysis is also needed to study the appropriate doses and undesired effects of I3C supplements.

The work was developed at the Cancer Center and Cancer Research Institute of Beth Israel Deaconess Medical Center by Pandolfi and his team, representatives of institutions in the United States, Taiwan, China, Italy, Australia and India and supported by the National Institutes. of health.

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